MO210SERUM LEVELS OF PLASMINOGEN ACTIVATOR UROKINASE RECEPTOR AND CARDIOTROPHIN-LIKE CYTOKINE FACTOR 1IN PATIENTS WITH NEPHROTIC SYNDROME

Abstract Background and Aims The pathogenesis of primary focal segmental glomerulosclerosis (FSGS) minimal change disease (MCD) remains unknown to date. Some circulating permeability factors are discussed. This work assessed molecule candidates for in serum samples patients with nephrotic syndrome (NS). Method Forty-one chronic glomerulonephritis (CGN) were included our study. Seventeen had FSGS, 7 MCD, 5 membranoproliferative (MPGN), 6 IgA nephropathy, membranous nephropathy (MN). laboratory data compared the clinical histological features nephritis. Serum levels uPAR CLCF-1 measured by ELISA. Results plasminogen activator urokinase receptor (uPAR) higher FSGS before treatment than other morphological forms (MCD, MN MPGN). did not correlate daily proteinuria, creatinine/eGFR, arterial hypertension, number sclerosed glomeruli or tubulointerstitial fibrosis. No correlations found between cardiotrophin-like cytokine factor 1 (CLCF-1) creatinine levels/glomerular filtration rate, percentage severity There no significant differences variants However, we proteinuria (Rs = 0. 397, p 0.015) triglycerides 475, 0.003). Conclusion indicate an increase treatment. do depend on CGN, kidney function immunosuppressive treatment, but they lipids NS.